CBGA is an acidic cannabinoid that has been gaining attention from the science community and consumers alike. And for good reason. Research has found CBGA has the potential to help with a wide range of diseases and ailments and works better in many instances than its neutral counterpart CBG. Unlike most cannabinoids that bind to CB1 and CB2, CBGA does not. Instead, CBGA has important off target effects, such as activating PPARs to deliver its therapeutic effects. In this guide we will discuss the current research findings on CBGA and future possibilities in therapeutic applications.
CBGA for Metabolic Disorders
Research has found CBGA could be a potential plant-derived therapeutic for patients with metabolic disorders, including Type 2 diabetes, Cushing’s disease, Addison’s disease, and Grave’s disease. CBGA acts as a dual PPARa/y agonist. Through the activation of PPARs, CBGA can reduce the accumulation of fat tissues and improve the lipid metabolism. This can in turn reduce insulin resistance in Type 2 diabetes patients. Additionally, CBGA can inhibit the enzyme aldose reductase, a key enzyme involved in diabetic complications including cardiovascular, eye, and nerve damage, as well as the progression of neuropathy.
CBGA for Cancer
CBGA has exhibited cytotoxic activity in over 10 cancer cell lines, both with animal and human cell lines in vitro. More research needs to be done to confirm these findings. However, preliminary research shows CBGA may be a powerful acidic cannabinoid to help the millions suffering from cancer globally.
CBGA for Covid-19
Research has found both CBGA and CBDA has the potential to prevent the virus that causes Covid-19 from entering human cells when studied in vitro. CBGA and CBDA were able to block the cellular entry of Covid-19 by binding to the spike protein. This same action has the potential to help patients with hepatitis and HIV as well.
CBGA as an Antioxidant
CBGA has been found to have greater antioxidant activity than Vitamin E and CBG. By reducing and preventing oxidative stress, CBGA can help with a wide range of illnesses including, central nervous system disease, cancer, diabetes, and cardiovascular conditions. It also makes CBGA a great ally for the skin, as the antioxidant properties help to fight signs of aging, and can help with conditions, such as eczema and psoriasis.
CBGA as an Antibacterial
CBGA’s antibacterial properties can be leveraged in many ways including for oral health. CBGA acts as a potent antibacterial agent against a range of bacteria and has been found to have greater antibacterial properties for oral health than traditional toothpaste. In fact, it was found to be more effective at reducing dental plaque then the well-known Oral B and Colgate. Through this action CBGA can help prevent tooth decay, gum disease, and preserve oral health.
Products that can be made with CBGA to harness its therapeutic effects
CBGA isolate is a great way to incorporate CBGA into cannabinoid-based formulation. The high-purity extract typically has 95% or higher purity and is isolated from all other compounds in the hemp plant. The microcrystalline powder is odorless and tasteless, seamlessly blending into the formulation you desire. Here are some of the most sought-after products with CBGA:
CBGA Tinctures and Capsules
CBGA tinctures and capsules are made by infusing CBGA isolate into a carrier oil, such as MCT oil or olive oil. Tinctures and capsules offer a discreet and convenient way for consumers to take CBGA.
Toothpaste made with CBGA isolate has become a popular way to harness the antibacterial properties of CBGA. Many have reported decreased sensitivity and increased oral health when using CBGA oral care products.
CBGA Skincare Products
CBGA’s antioxidant properties make it a great additive to skincare products. It helps to combat aging, sooth irritated skin, and can help with eczema, psoriasis, and more. Some of the most requested products are moisturizers and cleansers.
CBGA Edibles and Beverages
The hemp edible and beverage market has been booming, with many consumers enjoying an alternative way to consume cannabinoids. Some of the most popular options include gummies, teas, and sparkling beverages.
When formulating a product with CBGA it is important to consult a trusted CBGA manufacturer throughout the process. They can advise and guide you through the process to ensure the temperatures are ideal to avoid a conversion of CBGA to CBG.
CBGA is a minor acidic cannabinoid with the potential to be used in major ways. Research has found it has the potential to help with a range of diseases and ailments, some of which have very little treatment options. As research continues CBGA will be a plant-derived therapeutic that can help many across the globe.