Cannabinoids have become increasingly popular, as they provide a wide range of benefits to those who consume it. Many know about CBD, however there are over 100 cannabinoids derived from the hemp plant we should be talking about, including the acidic ones. CBGA is an acidic cannabinoid that has been gaining attention from both consumers and the scientific community alike for the benefits it can potentially deliver. Let’s explore the potential benefits of CBGA isolate and what makes it ideal for introducing CBGA into existing cannabinoid-based formulations.
What’s CBGA Isolate?
CBGA isolate is a high-purity extract of CBGA that has been isolated from all other components in the hemp plant. It typically has 99% or higher purity, resulting in the purest and most potent form of CBGA available on the market. CBGA isolate is often odorless and tasteless, making it the ideal choice to introduce CBGA into cannabinoid formulations.
Potential Health Benefits of CBGA Isolate
Research into the benefits of CBGA has found it has the ability to help with a wide range of conditions. Here are the benefits of CBGA:
CBGA for Metabolic Disorders
CBGA has the potential to help with an array of metabolic disorders, including Type 2 Diabetes, Cushing’s disease, Addison’s disease, and Grave’s disease, by acting as a dual PPARa/y agonist. Through activation of PPARs, CBGA can improve lipid metabolism and reduce the accumulation of adipose tissue; thus, reducing insulin resistance in Type 2 Diabetes patients. Additionally, CBGA can inhibit the enzyme aldose reductase, a key enzyme involved in diabetic complications including cardiovascular, eye, and nerve damage, as well as the progression of neuropathy.
CBGA for Cancer
CBGA has demonstrated cytotoxic activity in over 10 cancer cell lines, both with animal and human cell lines in vitro. This could benefit a wide range of cancers, such as leukemia, breast cancer, and brain cancer. With millions being affected by cancer annually, it is prominent more research is done.
CBGA for Covid-19
Research has found both CBGA and CBDA have the ability to prevent the virus that causes COVID-19 from entering human cells by binding to the spike protein in vitro, thus blocking the cellular entry of SARS-Cov-2. The research suggests CBGA and CBDA could potentially prevent and treat COVID-19. This same type of action could also benefit patients with HIV and hepatitis.
CBGA antioxidant effects
CBGA has demonstrated greater antioxidant activity than CBG and Vitamin E. This makes CBGA a potential therapeutic for conditions that involve oxidative stress including, central nervous system disease, and cardiovascular conditions. This also makes CBGA a great component in skincare products, as the antioxidant effects help to rejuvenate and protect aging skin.
CBGA antibacterial effects
CBGA acts as a potent antibacterial agent against a wide range of bacteria, including s. mutans and dental plaque. Additionally, research has found CBGA acts as a more powerful anti-bacterial to support dental and mouth health than traditional toothpaste, making it a beneficial additive to oral care products.
Products that can be made with CBGA Isolate
CBGA isolate has the potential to be transformed into a diverse array of products. Nonetheless, it is essential to avoid introducing high temperatures during the manufacturing process to prevent the conversion of CBGA to CBG. This conversion would render the crafting of smokable products with CBGA impossible, but the possibilities for other products are nearly limitless. Below are some of the most sought-after items that can be produced using CBGA isolate.
- Skincare products, such as moisturizers, toners, and face washes
- Oral care products, such as toothpaste, and mouthwash
- Topicals, such as lotion and patches
CBGA is a minor cannabinoid with the potential to be used in major ways. CBGA makers all over the world are harnessing the benefits this powerful acidic cannabinoid has and elevating their products by incorporating CBGA isolate. It can be infused into a wide range of product applications and as research continues, soon we will know of the many other benefits CBGA holds.
Anti-Diabetic Effect of CBGA in STZ Induced Diabetic Rats_Journal of Cardiovascular Disease Research_2021.pdf – Google Drive
Analysis of Anti-Cancer and Anti-Inflammatory Properties of 25 High-THC Cannabis Extracts_Molecules_2022.pdf – Google Drive