CBD has become increasingly popular with an average of 1 in 7 adults in the United States using a CBD product to elevate their health and wellness. And for great reason, as it has many benefits it can deliver. However, research has found its precursor, CBDA, works even better than the well-known CBD. Let’s explore the benefits of CBDA and what makes it superior to CBD.
What is CBDA?
CBDA is an acidic cannabinoid that is sourced from the hemp plant. Contrary to the belief that CBD is the most prominent cannabinoid in the hemp plant, it is actually CBDA. This is because when the hemp plant is grown it produces CBDA, not CBD. CBD is the result of decarboxylating CBDA, a process where cannabinoids are exposed to natural or artificial heat sources.
CBDA only recently became available in a stable form to infuse into product applications, and interest in CBDA has grown quickly. This is because not only does it provide a wide range of benefits, but it has been found to be an astoundingly 19x more bioavailable than CBD. This means when an equivalent dose of CBD and CBDA are administered, the body can absorb much more CBDA. This makes CBDA a more powerful therapeutic for a variety of instances and also allows for lower doses to feel therapeutic effects. Many have taken notice including GW Pharma. They currently make Epidiolex, an FDA approved drug with CBD for seizure disorders. They are now seeking approval for another patent, this time with CBDA as an anticonvulsant. Within the patent, it was cited patients would need less CBDA than CBD to achieve the desired effects, accrediting CBDA’s bioavailability.
Benefits of CBDA
Research has found CBDA has the potential to provide a wide range of benefits, with even more being discovered as research continues. Here are some of the potential benefits of CBDA:
CBDA for Inflammation
CBDA produces anti-inflammatory effects via its role as a COX-2 enzyme inhibitor. Most COX-2 inhibitors, such as aspirin, also inhibit COX-1 causing gastrointestinal complications. CBDA does not, making it a safer option to relieve inflammation, having the potential to help with an array of inflammatory conditions including, inflammatory bowel diseases, arthritis, and fibromyalgia.
CBDA for Hyperalgesia
Along with reducing inflammation, CBDA has also been found to reduce hyperalgesia. Hyperalgesia is an increased sensitivity to pain that occurs when there is damage to the nerves or chemical changes to the nerve pathways. Hyperalgesia can be induced from nerve and tissue injuries, chronic pain, as well as long-term opioid use. CBDA’s ability to reduce hyperalgesia suggests it can help with a wide range of chronic pain conditions.
CBDA for Anxiety and Depression
CBDA activates the 5-HT1A or serotonin receptor producing a wide range of therapeutic effects, including reducing both anxiety and depression. Activation of the receptor is a crucial component in anti-anxiety, anti-depressant, and anti-psychotic pharmaceuticals, making CBDA a promising plant-derived therapeutic.
CBDA for Nausea and Vomiting
Activation of the 5-HT1A receptor also helps to reduce feelings of nausea and decrease the frequency of vomiting. Research has found CBDA activates the receptor much greater than CBD, suggesting CBDA is a more powerful therapeutic for an array of ailments, such as nausea, vomiting, anxiety, and depression.
CBDA acts as an Antioxidant
CBDA has been found to have greater antioxidant activity than Vitamin E and CBD. CBDA has the ability to scavenge free radicals, protect oxidative processes, and reduce metal ions. This could benefit a wide range of diseases including, central nervous system diseases and cardiovascular conditions caused by oxidative stress. Additionally, CBDA could be a great additive to skincare products, as the antioxidant properties help to protect aging skin and can reverse damage caused by free radicals.
Products that can be made with CBDA
When manufacturing products with CBDA, it is best to introduce CBDA into the formulation by the way of an isolate. CBDA isolate is the purest and most potent form of CBDA available on the market, typically with 99% or greater purity. CBDA isolate is often odorless and tasteless, having the potential to be easily transformed into a diverse array of products. When manufacturing CBDA products, it is essential to avoid introducing high temperatures during the manufacturing process to prevent the conversion of CBDA to CBD. This conversion would render the crafting of smokable products with CBDA impossible, but the possibilities for other products are nearly limitless. Below are some of the most sought-after items that can be produced using CBDA isolate.
- Skincare products, such as moisturizers, toners, and face washes
- Oral care products, such as toothpaste, and mouthwash
- Topicals, such as lotion and patches
CBDA is a minor cannabinoid with the potential to be used in major ways. It has a wide range of benefits and in many ways is better than the well-known CBD. CBDA manufacturers all over the world are harnessing the benefits this powerful acidic cannabinoid has and elevating their products by incorporating CBDA isolate into them. It can be infused into a wide range of product applications and as research continues, soon we will know of the many other benefits CBDA holds.
Anxiety and Depression
Nausea and Vomiting
Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5‐HT1A receptor‐mediated suppression of nausea and anxiety in rats – Pertwee – 2018 – British Journal of Pharmacology – Wiley Online Library