CBDA recently became available in a stable form to infuse into cannabinoid-based formulations, bringing more products with CBDA to the market. This along with emerging research has both consumers and those in the field of science keeping a close eye on this minor acidic cannabinoid that has demonstrated it can be used in major ways. CBD is a cannabinoid most have heard about, but it is time to shift the spotlight to its precursor CBDA. Let’s dive into a few ways CBDA has shown itself to be better than CBD.
In a study published in the 24th Annual Symposium of the International Cannabinoid Research Society, it was found CBDA is 19x more bioavailable than CBD. Bioavailability is the percentage or fraction of absorption of an administered drug or supplement that reaches the systemic circulation and is available to have effect. The findings mean our bodies absorb more CBDA in comparison to CBD, allowing for lower doses of CBDA for a variety of instances.
Both CBDA and CBD have demonstrated anti-seizure properties in numerous studies. CBD is the first cannabinoid to have FDA approval as a therapeutic for those with seizure disorders in the anticonvulsant drug, Epidiolex. GW Pharma, the maker of Epidiolex, filed a patent in 2015 regarding the use of a therapeutically effective amount of CBDA in the treatment of epilepsy. The findings within the patent found CBDA offers an alternative anti-convulsant option to CBD, siting CBDA is more bioavailable and in turn more effective at treating seizures than CBD. Additionally, it was found patients will require much lower doses of CBDA to control seizures in comparison to CBD.
Greater Affinity for Serotonin Receptors
The bodies serotonin receptor is most known for its role in controlling mood. However, it is responsible for modulating dozens of critical processes in the body including pain signals, nausea and vomiting, and the cardiovascular system. Through research, CBDA has demonstrated a greater affinity to the bodies 5HT1-A or serotonin receptor. In a 2013 study CBDA showed a 100-fold greater affinity to the serotonin receptor than CBD, allowing for lower doses of CBDA for a variety of instances including reducing nausea and vomiting, and as a therapeutic for patients with anxiety disorders and depression.
Should I take CBD or CBDA?
Both CBDA and CBD can be beneficial when added into a health regimen. Each individuals’ needs are dependent on what they are trying to achieve with cannabinoids. When taken together or paired with other cannabinoids, both CBDA and CBD leverage the entourage effect. This is when compounds work together synergistically to modulate and boost the effects of their singular parts, allowing the body to achieve a state of homeostasis easier. Always speak to your primary care physician before adding any supplements into your daily wellness routine to help determine what is best for you.