Research based articles

Similarities of CBDA & CBD

Many have heard of CBD. After all it is in most major retailers now and has even made its way into the gift bags at the Oscars. Its precursor, CBDA, has been gaining more attention as of late and for good reason. CBDA has demonstrated a host of therapeutic benefits through research and has even shown itself to be more beneficial in some instances than CBD. The two cannabinoids are closely related and share likenesses and differences. In this guide we are going to review some of the ways the cannabinoids are similar to one another.

CBDA creates CBD

CBDA is the acidic precursor to CBD. When CBDA is decarboxylated, a process where cannabinoids are exposed to heat, CBDA converts to CBD. Due to the wide range of benefits CBDA holds, some cultivators are now using selective breeding to yield plants higher in CBDA.


Both CBDA and CBD are non-psychoactive cannabinoids, meaning they will not get you high like the commonly known Delta 9 THC. In fact, CBD has been shown to counteract the euphoric effects of Delta 9 THC that can be uncomfortable for some.


CBD and CBDA have demonstrated great therapeutic value through research. Though CBD has been studied more extensively than CBDA, up and coming research shows CBDA is not a cannabinoid that should be overlooked.
Both CBDA and CBD have an affinity to our serotonin or 5-HT1A receptor showing them both beneficial in an array of instances including helping those with anxiety disorders, depression, and nausea and vomiting. Though both have an affinity, research has demonstrated CBDA has a 100-fold greater affinity than CBD, allowing for lower doses of CBDA in these instances.
CBD and CBDA both have anti-seizure properties. CBD is part of Epidiolex, an FDA approved therapeutic for various seizure disorders involving a fixed ratio of plant derived CBD, from GW Pharma. In 2015 GW Pharma filed a patent regarding the use of CBDA in the treatment of epilepsy. The patent found CBDA offers an alternative option to CBD, citing CBDA was more effective at treating seizures than CBD due to its higher bioavailability.

Product Applications

Both CBDA and CBD are available in a wide range of cannabinoid-based products. Some of these products include:
  • Tinctures
  • Topicals
  • Beverages
  • Edibles
  • Capsules
It is important to note that though some inhalation products on the market today advertise themselves as CBDA, they are not. When CBDA is heated it converts to CBD, so as soon as you light that “CBDA flower,” it becomes CBD.

Entourage Effect

Both CBD and CBDA enact the entourage effect when taken together or alongside other cannabinoids. The entourage effect is when compounds work synergistically together to modulate and boost the effects of the singular compound. This allows the body to achieve a state of homeostasis better and boost the benefits of the cannabinoids when taken together.
Both CBD and CBDA can be great cannabinoids to add into one’s daily wellness routine. Always check with your primary care physician before adding any supplement into your health regimen.
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