Research based articles

The Benefit of Adding THCA Isolate Into Cannabinoid-based Formulations

THCA is a minor acidic cannabinoid that can have a major impact when it is added into cannabinoid-based formulations. These high-purity extracts allow consumers to fully gain the benefits THCA has to offer and can easily be infused into a wide range of product applications. In this guide we will discuss some commonly asked questions about THCA isolate.

What is a THCA isolate?

THCA isolate is a high-purity extracts of the acidic cannabinoid. They typically have 99% or higher purity. When extracting THCA, it is crucial no heat is used in the process to avoid any conversion of THCA to its neutral counterpart, THC. At Essentia Scientific, we created our patented water-as-solvent technology that eliminates the need for heat in the extraction process, allowing us to extract all acidic cannabinoids, including THCA, CBDA, and CBGA, at a mass scale.

What is the difference between THCA isolate and THC isolate?

Though THCA and THC are closely related, they are not the same. THCA serves as the precursor to THC. This means when THCA is decarboxylated, a process where cannabinoids are exposed to heat, it converts to THC. On its own, it has demonstrated great therapeutic value and continues to gain consumer interest.
THCA interacts with many of the same receptors as Delta 9 THC, suggesting they deliver similar therapeutic benefits. However, research has found THCA has some advantages when compared to THC, including its heightened bioavailability. THCA also has demonstrated a great binding affinity for PPARy when compared to Delta 9 THC, which plays a crucial role in the regulation of metabolic and inflammatory signaling pathways. Through this action THCA can potentially help with a wide range of metabolic disorders and inflammatory conditions.
Unlike Delta 9 THC which is psychotropic, THCA is not. Rather than inducing euphoria, THCA leaves consumers feeling calm and clear-headed. This makes it a great choice to gain the benefits consumers love from THC, but without the uncomfortable euphoria.

What are the potential benefits of THCA isolate?

THCA isolate has been found to have the potential to help with a wide range of conditions, including inflammatory illnesses, such as arthritis, and skin conditions though its powerful antioxidant activity. Here are some of the many benefits of THCA:

THCA Antioxidant Benefits

Research has found THCA acts as a powerful antioxidant, even more so than Vitamin E. Antioxidants help to promote homeostasis in the body and have powerful disease-fighting properties. It is also great additive to skin care products to soothe irritated skin, and redness, and to combat free radicals that cause wrinkles with aging.

THCA Anti-Inflammatory Benefits

THCA interacts with both the COX-2 enzyme and PPARy, which both play dominant roles in inflammatory signaling pathways. In fact, research has found THCA demonstrates a greater binding affinity to PPARY than all other minor cannabinoids, including CBDA and CBGA, suggesting it acts as a more potent anti-inflammatory and has the potential to help with a wide range of inflammatory illnesses and injuries.

THCA Anti-Nausea Benefits

Research has found THCA can reduce nausea at doses much lower than Delta 9 THC.

THCA Anti-Anxiety benefits

THCA reduces anxiety by interacting with the body’s serotonin or 5-HT1A receptor. The receptor is most known for its role in mood support. However, it is responsible for modulating many critical processes in the body including, nausea and pain signals.
Along with the benefits above, research has found THCA can potentially help patients with metabolic disorders, such as type 2 diabetes. Anecdotal evidence has also discovered THCA may act as an anti-convulsant, with even greater therapeutic potential than that of CBD, which is currently approved by the FDA for use as an anti-convulsant. As more research is concluded, we will know of even more benefits THCA holds.

What products can be made with a THCA isolate?

THCA isolate can be easily introduced to existing cannabinoid-based formulations. It can be added on it’s own to create a high-purity THCA product or blended with other cannabinoids and terpenes to create a unique therapeutic blend. There are a wide range of products THCA isolate can be introduced to including:
  • Orally ingested products, such as tinctures, beverages, and edibles.
  • Topical products, including skin care, lotions, and patches.
When formulating a product with THCA or any other acidic cannabinoid, it is important no high heat is introduced in the process to avoid any conversion of the acidic cannabinoid to its neutral form. This also eliminates the option for crafting a smokable with acidic cannabinoids.

Where is THCA isolate legal?

THCA is federally legal if it is derived from hemp, as long as the final product contains 0.3% or less of Delta 9 THC. If THCA is derived from cannabis, it is not federally legal, though there are many states where it holds legal status, including Washington, California, Nevada, and Colorado.
THCA isolates can be a great addition to cannabinoid-based formulations. It delivers a wide range of benefits, without inducing euphoria that can be uncomfortable for many consumers.
Contact us today for high-purity pharmaceutical-grade THCA extracts, made with the highest manufacturing standards.
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