Research based articles

What is CBGA & What Does it Do?

CBGA is a minor cannabinoid with the potential to be used in major ways. It is packed with benefits and is crucial to the formation of other cannabinoids that we know and love, such as CBD and THC. In this guide we will discuss what CBGA is, and what it does for us and the hemp and cannabis plant.

What is CBGA?

CBGA is known as the “mother of all cannabinoids” as it is the foundational acidic cannabinoid crucial to the formation of other cannabinoids, including THCA and CBDA. CBGA is the first cannabinoid in the hemp plant to be produced, leading the way for other cannabinoids to develop. Not only does CBGA create other cannabinoids, but it also helps to regulate plant growth including leaf size and shape. Additionally, CBGA protects the plant from outside stressors like UV radiation and pest. CBGA is crucial not only for the plant’s growth and development, but for its survival as well. CBGA is available in small quantities for extraction in the mature hemp plant, as most of CBGA has converted to other cannabinoids. Because of this some cultivators are using selective breeding to yield plants with higher concentrations of CBGA.

What are the benefits of CBGA?

While there is less research on CBGA compared to other cannabinoids, research has shown CBGA may be a therapeutic for an array of conditions and ailments. CBGA does not bind directly with CB1 or CB2 receptors like most cannabinoids, instead it has important off target effects, such as activating PPARs, that are responsible for CBGA’s therapeutic benefits. Here are some of CBGA’s most notable benefits:

CBGA for Metabolic Disorders

CBGA has demonstrated itself as a therapeutic for those with metabolic disorders, such as diabetes. Through the activation of PPARs, CBGA can improve lipid metabolism, and reduce the accumulation of adipose tissue, thus reducing insulin resistance in patients with type 2 diabetes. Additionally, CBGA inhibits the enzyme aldose reductase, a key enzyme involved in diabetic complications including cardiovascular, eye and nerve damage, as well as the progression of neuropathy.

CBGA for Covid-19

A 2022 Oregon State University propelled CBGA into the media spotlight after researchers there found CBGA could prevent the virus that causes COVID-19 from entering cells by binding to the spike protein when tested in vitro. This action then blocks the cellular entry of the virus. This same mechanism of action has also helped patients with hepatitis and HIV.

CBGA for Cancer

CBGA may be beneficial in treating various types of cancers. Through research, CBGA demonstrated cytotoxic activity against colon cancer cells, while also preventing the growth of colon polyps. Additionally, when CBGA was introduced to human leukemia cancer cell lines at micromolar concentrations, it also had cytotoxic actions. With cancer being responsible for millions of deaths globally, the need for continued research is immediate.

How can I use CBGA?

There are numerous ways you can use CBGA to improve your health. Here are some of the most common routes of administration:

CBGA Tinctures

Tinctures are one of the most popular ways to ingest cannabinoids. Tinctures are typically made with a carrier oil, such as MCT oil or olive oil, and blended with the cannabinoid extract. They are taken orally under the tongue or can be added to your favorite smoothies or beverages.

CBGA Isolate

Isolates are a great way to get the benefits of CBGA. Isolates are the cannabinoid in its pure form, usually with 99% or higher purity. The microcrystalline powders have no taste and can be easily added into almost anything.

CBGA Capsules

CBGA capsules are typically tinctures put into a capsule form to avoid the earthy flavor some have. Capsules are a quick and easy way to administer cannabinoids and make dosing easy and accurate.

Is CBGA Legal?

Yes, CBGA that comes from hemp is legal in the United States. The 2018 Farm Bill removed hemp from the list of controlled substances, making it legal to grow and consume hemp products with less than 0.3% of Delta 9 THC.
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