Research based articles


CBDA is an interesting acidic cannabinoid that is just starting to gain attention in the world of hemp as it now available in a stable microcrystalline form, ready to be infused into cannabinoid applications, bringing more products with CBDA to the market for consumers. It is one of the most abundant cannabinoids found in raw hemp, and it has some unique benefits that you won’t find with other cannabinoids.

In this guide, we will discuss what CBDA is, what its benefits are, and how you can use it to improve your health!

What is CBDA?

CBDA is a non-psychoactive acidic cannabinoid that serves as a precursor to CBD. More specifically, when heated CBDA is decarboxylated to create CBD. However, on its own CBDA has shown great therapeutic potential having cultivators use selective breeding to get more of this acidic cannabinoid from the plant and global solutions providers are producing ways to extract this amazing cannabinoid so more can get the benefits it brings. What are the benefits of CBDA? CBDA has a number of therapeutic benefits. Some of its most notable benefits include:

Anti-Anxiety and Anti-Depressant

Anxiety and depression are one of the most common mental illness disorders affecting 40 million people annually in the United States alone. Through research CBDA has demonstrated itself as a potential therapeutic for those with anxiety and depression through its interaction with our serotonin receptor, 5-HT1A. In a 2013 study CBDA enhanced 5-HT1A receptor activation.

When compared to CBD, CBDA displayed a 100-fold greater affinity to the receptor, demonstrating CBDA more effective at reducing anxiety than CBD.

For anxiety and depression activating the 5-HT1A receptor is a crucial component to help those suffering and CBDA is showing itself as a promising plant derived therapeutic option for patients.

Anti-Inflammatory Properties

Inflammation in the body can be caused by an array of factors, and long-term inflammation can lead to disease and injury overtime within the body including damage to muscles, organs, and tissues. Through research CBDA has demonstrated its potential to reduce inflammation via its role as a COX-2 enzyme inhibitor. COX-2 has an anti-inflammatory effect that non-steroidal anti-inflammatory drugs, such as aspirin, also inhibit. As a COX-2 inhibitor, studies have demonstrated CBDA as  a safer option for anti-inflammatory effects than the current options available on the market today.


Analgesic Effects

Pain effects many people with both chronic and acute ailments. CBDA has demonstrated analgesic properties by reducing pain caused by inflammation and hyperalgesia. In a 2018 study CBDA was given to a rodent model and produced dose dependent anti-hyperalgesia and anti-inflammatory effects. In addition, to compare CBDA and CBD an equivalent dose of CBD was administered in the rodent model and did not reduce hyperalgesia nor inflammation, suggesting CBDA is more potent than CBD in this indication.


Cancer is a serious disease that effects millions worldwide. CBDA can potentially help in reducing the growth of cancer cells. Through research CBDA was effective in inhibiting the growth of breast cancer cells. While in another study, CBDA killed colon cancer cells. As more research is conducted, CBDA may show itself as a potential therapeutic for those suffering from cancer.

Reduces Nausea and Vomiting

Nausea and vomiting can be caused by a lot of factors such as gastrointestinal disorders, medication induced vomiting, and even emotional stress can induce nausea. In a 2013 study CBDA enhanced 5-HT1A receptor activation, reducing vomiting and nausea.

When compared to CBD, CBDA displayed greater affinity for 5-HT1A demonstrating CBDA is more potent at reducing nausea in comparison to CBD.

CBDA is a minor cannabinoid that through research has demonstrated the potential to be used in major ways for a variety of therapeutic uses. As more research is conducted, more benefits will be uncovered and solidified for this amazing acidic cannabinoid.

How can I use CBDA?

There are a number of ways that you can use CBDA to improve your health. Here are a few of the most popular methods:


CBDA tinctures are one of the most popular ways to use this cannabinoid. Tinctures are a liquid extract that can be taken orally. They are made by adding the cannabinoid into a carrier oil such as olive oil or MCT oil. Tinctures are an easy and convenient option for consumers. Simply put under your tongue or add into your favorite beverage or smoothie.



CBDA can also be used in topical applications like lotions or massage oils. This can be helpful in not only gaining the benefits CBDA has internally once absorbed, but also bringing benefit to our skin.



Is CBDA legal?

Yes, CBDA that comes from hemp is legal in the United States. The 2018 Farm Bil removed hemp from the list of controlled substances, making it legal to grow and consume hemp products with less than 0.3% THC.

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