Research based articles

The Science behind CBDA Isolate: How it works in the body

As more and more consumers discover the numerous benefits and advantages of CBDA, this acidic cannabinoid has surged in popularity. With a growing number of individuals turning to cannabinoid-based products to support their overall health and well-being, CBDA isolate has emerged as a highly sought-after compound, many are calling the “New CBD.” In this article, we will discuss the science behind how CBDA works in the body.

What is CBDA isolate?

CBDA isolate is a high-purity extract of the acidic cannabinoid that has been isolated from all other components in the hemp plant. It typically has 98% or higher purity, making isolate an excellent choice to introduce CBDA into existing cannabinoid-based formulations. Additionally, it is often odorless and tasteless, seamlessly blending into formulations.

How does CBDA work in the body?

Unlike CBD that has a binding affinity to CB1 and CB2, CBDA has a low affinity to the receptors. Instead, it has important off-target effects, such as inhibiting COX-2, to deliver its therapeutic effects. Let’s delve into some of the most prominent therapeutic effects that research has discovered for CBDA.

Anti-Anxiety and Anti-Depressant Effects of CBDA

CBDA activates the 5-HT1A or serotonin receptor. Activation of the receptor is a crucial component in anti-anxiety, anti-depressant, and anti-psychotic pharmaceuticals. Research suggests CBDA could be a plant-derived therapeutic for patients with an array of mental illnesses, without inducing harmful side-effects that can accompany many current pharmaceuticals. When compared to CBD, CBDA displayed a greater affinity to the receptor.

Anti-Nausea Effects of CBDA

Through the same action CBDA produces its anti-anxiety and anti-depressant effects, CBDA can also reduce nausea. While the 5-HT1A receptor is most recognized for its role in mood support, it modulates dozens of processes in the body, including nausea. This makes CBDA a potential option for those with chemotherapy-induced nausea, motion sickness, foodborne illness, and medication induced nausea.

Anti-Inflammatory Effects of CBDA

CBDA acts as a COX-2 enzyme inhibitor. This is the same enzyme non-steroidal anti-inflammatory pharmaceuticals also target. However, current pharmaceuticals also inhibit COX-1, which cause gastrointestinal upset. Since CBDA does not, it makes it a promising option for those needing to reduce inflammation without causing unwanted side-effects.

Anti-Hyperalgesia Effects of CBDA

CBDA has been found to reduce hyperalgesia in rodent models. Hyperalgesia occurs when there is damage to the nerves or chemical changes to the nerve pathways, increasing sensitivity to pain. This can occur from nerve and tissue injuries, as well as long term opioid use. This makes CBDA a promising plant-derived option for those with chronic pain conditions, such as fibromyalgia and spinal injuries and diseases.

Anti-Seizure Effects of CBDA

CBDA acts as a potent anti-convulsant, even more so than CBD. CBD is currently the only cannabinoid with FDA approval for use as an anti-convulsant. However, the maker is seeking the approval of a drug with CBDA instead of CBD, citing CBDA worked better than CBD at reducing the frequency and duration of seizures. Additionally, patients would need much lower doses of CBDA to achieve the desired therapeutic effects.

Antioxidant Effects of CBDA

CBDA can scavenge free radicals, protect oxidative processes, and reduce metal ions. It has been found to have greater antioxidant activity than Vitamin E as well as CBD. While this makes CBDA a great additive to skincare products to promote skin health. It also means CBDA could benefit a wide range of ailments and diseases, such as cancer, central nervous system disease, and other chronic conditions caused by oxidative stress.

Anti-Bacterial Effects of CBDA

CBDA has demonstrated inhibitory effects against a wide range of bacterium, including S. aureus. S. aureus is a bacterial infection that has demonstrated drug resistance to a wide range of antibiotics and is one of the 12 bacterial infections listed by the World Health Organization that poses a threat to global health. CBDA’s ability to inhibit the bacteria suggests it may help with bacterial infections that has developed a resistance to standard antibiotics.

Does CBDA work better than CBD?

CBDA is superior in many ways when compared to CBD. A study published in the 24th Annual Symposium of the International Cannabinoid Research Society found CBDA is 19x more bioavailable than CBD. This makes it a more powerful therapeutic for a variety of instances and allows for lower doses to experience the therapeutic benefits. Additionally, research has found CBDA has a greater binding affinity to a variety of receptors. When using CBD and CBDA, one is able to feel greater effects from CBDA.
CBDA is an acidic cannabinoid that holds great potential in supporting overall health and well-being. Its therapeutic benefits are numerous, and it has shown promise in helping with a range of diseases. As we have reviewed, CBDA works in the body in a unique and powerful way, making it a superior alternative to CBD in many respects. With further research, CBDA could prove to be a valuable addition to the natural remedies available to us today.
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